\u6587\/ \u9ed1\u7231\u83b2 \u535a\u58eb<\/em><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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2023\u5e742\u670817\u65e5\uff0c\u7531\u6df1\u5733\u5e02\u827e\u4f26\u65af\u6587\u7cbe\u51c6\u533b\u5b66\u7814\u7a76\u6240\u8054\u5408\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5171\u540c\u5b8c\u6210<\/strong>\u7684\u300aIs serum thymidine kinase 1 a prognostic biomarker in primary tumor location of colorectal carcinomas?\u300b\u4e00\u6587\u5728\u56fd\u9645\u80bf\u7624\u9886\u57df\u4e13\u4e1a\u671f\u520a\u300aDiscovery Oncology\u300b(\u5f71\u54cd\u56e0\u5b50 4.667)\u4e0a\u516c\u5f00\u53d1\u8868\uff0c\u9996\u6b21\u8be6\u7ec6\u62a5\u9053\u4e86\u4f53\u53ef\u95ee^{\u00ae\ufe0f<\/sup>TK1\u6307\u6807\u5728\u4e0d\u540c\u539f\u53d1\u80bf\u7624\u4f4d\u7f6e\u7684\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u9884\u540e\u4ef7\u503c\u3002<\/strong><\/p>\n\u8be5\u7814\u7a76\u7531\u8457\u540dTK1\u4e13\u5bb6Sven Skog\u6559\u6388\u3001Ellen He\u6559\u6388\u53ca\u7ed3\u76f4\u80a0\u764c\u9886\u57df\u6743\u5a01\u4e34\u5e8a\u4e13\u5bb6\u4e07\u5fb7\u68ee\u6559\u6388\u8054\u5408\u8bbe\u8ba1<\/strong>\uff0c\u5229\u7528488\u4f8b\u7ed3\u76f4\u80a0\u60a3\u8005\u4f5c\u4e3a\u7814\u7a76\u5bf9\u8c61\uff0c\u672f\u540e\u968f\u8bbf108\u4e2a\u6708\uff0c\u91c7\u7528\u56de\u987e\u6027\u7814\u7a76\u5206\u6790\u65b9\u6cd5\uff0c\u7814\u7a76\u4e86\u5305\u62ec<\/strong>\u4f53\u53ef\u95ee<\/strong>^{\u00ae\ufe0f<\/sup>T<\/strong>K1<\/strong>\u6307\u6807\u5728\u5185\u76847\u4e2a\u56e0\u7d20\u5728\u7ed3\u76f4\u80a0\u764cPLT\u4e2d\u7684\u9884\u540e\u4ef7\u503c<\/strong>\uff0c\u7814\u7a76\u7ed3\u679c\u5f97\u5230\u4e86\u56fd\u9645\u540c\u884c\u7684\u9ad8\u5ea6\u8ba4\u53ef\u3002<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/p>\n
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\n\n<\/p>\n<\/section>\n<\/section>\n\n\n\n\n\n\n\n\n\n\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n\n\n\n\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n\n\n\n\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n\u534e\u745e\u540c\u5eb7<\/strong>\u4f53\u53ef\u95ee^{\u00ae\ufe0f<\/sup>TK1<\/strong>\u8bd5\u5242\u76d2\u91c7\u7528\u9e21\u6297\u4ebaTK1-IgY\u6297\u4f53\u6280\u672f\uff0c\u662f\u4e00\u79cd\u6d4b\u5b9aSTK1p\u7684\u9ad8\u654f\u611f\u3001\u9ad8\u7279\u5f02\u6027\u7684\u68c0\u6d4b\u65b9\u6cd5\u3002<\/strong><\/section>\n\u5229\u7528\u8be5TK1-IgY\u6297\u4f53\u68c0\u6d4b\u76f4\u80a0\u764c\u60a3\u8005\u672f\u524d\u8840\u6e05\uff0c\u5728\u5929\u7136\u80f6Western Blotting\u4e2d\u4ec5\u663e\u793a\u5355\u4e00TK1\u6761\u5e26(\u4e0b\u56feAa-1,2)\u3002\u4f46\u672f\u540e6\u4e2a\u6708\u7684STK1p\u6c34\u5e73\u663e\u8457\u964d\u4f4e\uff0c\u51e0\u4e4e\u770b\u4e0d\u5230TK1\u6761\u5e26(\u4e0b\u56feAa-3)\uff0c\u63a5\u8fd1\u5065\u5eb7\u5bf9\u7167\u7ec4\u6c34\u5e73(\u4e0b\u56feAa-4,5)\u3002\u5728\u4e34\u5e8a\u5206\u671f\u4e3aT1N2M0\u7684\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\uff0cTK1\u4e3b\u8981\u5728\u764c\u7076\u7ec4\u7ec7\u7684\u7ec6\u80de\u8d28\u4e2d\u53d1\u73b0\u5f3a\u67d3\u8272(\u4e0b\u56feAb)\u3002ROC\u7edf\u8ba1\u5206\u6790\uff0cAUC\u503c\u4e3a0.88\u3002\u5728cut-off\u503c\u4e3a0.9pM\u65f6\uff0c\u9633\u6027\u4f3c\u7136\u503c\u4e3a8.3\uff0c\u654f\u611f\u6027\u4e3a0.65\uff0c\u7279\u5f02\u6027\u4e3a0.93\u3002\u9ad8AUC\u548c\u9633\u6027\u4f3c\u7136\u503c\u8868\u660e\uff0c<\/strong>\u4f53\u53ef\u95ee^{\u00ae\ufe0f<\/sup>TK1\u662f<\/strong>\u4e00\u4e2a\u53ef\u9760\u7684CRC\u8840\u6e05\u751f\u7269\u6807\u5fd7\u7269\u68c0\u6d4b\u6307\u6807\u3002<\/strong><\/section>\n<\/section>\n\n\n<\/p>\n<\/section>\n<\/section>\n\n\n\n\n\n\n\n\n\n\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n\n\n\n\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n\n\n\n\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n\u901a\u8fc7COX\u548c\u603b\u751f\u5b58\u671f(OS)\u7edf\u8ba1\u5206\u6790\u53d1\u73b0\uff0c\u5728RC\u548cL-CC\u4e2d\uff0cSTK1p\u503c\u7684\u5347\u9ad8\u4e0e\u603b\u751f\u5b58\u671f\u4e0b\u964d\u663e\u8457\u76f8\u5173<\/strong>(RC,P=0.002\uff1bL-CC,P=0.037)\uff0c\u800cCEA\u548cCA19.9\u5347\u9ad8\u4ec5\u5728RC\u4e2d\u4e0e\u603b\u751f\u5b58\u671f\u4e0b\u964d\u663e\u8457\u76f8\u5173(CEA,P\u2248.000; CA19.9,P\u2248.000), \u800c\u4e0eL-CC\u548cR-CC\u7684\u603b\u751f\u5b58\u671f\u65e0\u663e\u8457\u76f8\u5173\u6027(P>0.05)\u3002<\/section>\n<\/p>\n
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\n<\/em><\/span><\/h5>\n1.\u00a0Fang Y, Skog S, Ou Q, Chen Z, Liu S, Hei A, Li J, Zhou J, He E, Wan D. Is serum thymidine kinase 1 a prognostic \u00a0biomarker in primary tumor location of colorectal carcinomas? Discov Oncol. 2023 Feb 17;14(1):21. doi: 10.1007\/s12672-023-00614-5.<\/em><\/span><\/h5>\n2.\u00a0Zhou J, Li H, Fang C, Jin C, Liu S, Zou R, Li J, Liu Y, He E, Skog S. Concentration of human thymidine kinase 1 discover invisible malignant human tumours. Eur J Cell Biol. 2022;101(4):151280.\u00a0<\/em>https:\/\/doi.org\/10.1016\/j.ejcb.2022.151280.<\/em><\/span><\/h5>\n3.\u00a0Hei AL, Li J, Zhou J, He E, Skog S. IgY-polyclonal antibodies raised against C-terminal 31-peptide of human thymidine kinase 1 for detection of risk assessment in pre-carcinoma to carcinoma colorectal progression: a meta-analysis and systematic review. Ann Case Report. 2022. https:\/\/doi.org\/10.2901\/2574-7754.100803.<\/em><\/span><\/h5>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n","protected":false},"excerpt":{"rendered":"\u6587\/ \u9ed1\u7231\u83b2 \u535a\u58eb \u7ed3\u76f4\u80a0\u764c(CRC)\u662f\u5168\u7403\u7b2c\u4e09\u5927\u5e38\u89c1\u764c\u75c7\uff0c\u662f\u4e2d\u56fd\u7b2c\u4e8c\u5927\u5e38\u89c1\u764c\u75c7\uff0c\u4ec5\u6b21\u4e8e\u80ba\u764c\u3002\u57fa\u4e8e\u4e2d\u56fd2020\u5e74\u764c\u75c7\u6b7b\u4ea1\u6570\u636e\uff0c\u6bcf\u5929\u7ea6\u6709780\u4f59\u4eba(\u76f8\u5f53\u4e8e\u6bcf\u5c0f\u65f632\u4eba)\u56e0\u7ed3\u76f4\u80a0\u764c\u53bb\u4e16\uff0c\u6bcf\u65e5\u7ea6\u67091500\u4f59\u65b0\u53d1\u75c5\u4f8b\u3002\u63a2\u7a76\u65b0\u578b\u3001\u79d1\u5b66\u9002\u5b9c\u7684\u9884\u540e\u751f\u7269\u6807\u5fd7\u7269\uff0c\u6709\u5229\u4e8e\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2a\u4f53\u5316\u7cbe\u51c6\u6cbb\u7597\u548c\u5eb7\u590d\u3002 \u7ed3\u76f4\u80a0\u764c(CRC)\u6db5\u76d6\u7ed3\u80a0\u764c(CC)\u548c\u76f4\u80a0\u764c(RC)\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u7ed3\u76f4\u80a0\u764c\u7684\u539f\u53d1\u80bf\u7624\u4f4d\u7f6e(PTL)\u4e0d\u540c\uff0c\u75be\u75c5\u7279\u6027\u4e5f\u4f1a\u660e\u663e\u4e0d\u540c\u3002\u4f8b\u5982\u53f3\u7ed3\u80a0\u764c(R-CC)\u548c\u5de6\u7ed3\u80a0\u764c(L-CC)\uff0c\u4e24\u8005\u5728\u6d41\u884c\u75c5\u5b66\u3001\u4e34\u5e8a\u548c\u7ec4\u7ec7\u5b66\u7279\u5f81\u3001\u9884\u540e\u65b9\u9762\u662f\u4e0d\u540c\u7684\u3002\u8fd9\u79cdPTL\u590d\u6742\u6027\u589e\u52a0\u4e86\u7ed3\u76f4\u80a0\u764c\u9884\u540e\u8bc4\u4ef7\u7684\u96be\u5ea6\u3002\u5982\u679c\u80fd\u591f\u53d1\u73b0\u79d1\u5b66\u9002\u5b9c\u7684\u8840\u6e05\u9884\u540e\u751f\u7269\u6807\u5fd7\u7269\uff0c\u7ed3\u5408TNM\u5206\u671f\u7b49\u5176\u4ed6\u4e34\u5e8a\u6307\u6807\uff0c\u5c06\u4f1a\u6709\u52a9\u4e8e\u4e0d\u540cPTL\u7684CRC\u7684\u7cbe\u51c6\u9884\u540e\u8bc4\u4f30\uff0c\u6709\u5229\u4e8e\u63d0\u9ad8CRC\u60a3\u8005\u751f\u5b58\u9884\u6d4b\u7684\u51c6\u786e\u6027\uff0c\u964d\u4f4e\u75c5\u6b7b\u7387\u3002\u80bf\u7624\u7684\u672c\u8d28\u662f\u7ec6\u80de\u7684\u5f02\u5e38\u589e\u6b96\uff0c\u8840\u6e05\u7ec6\u80de\u589e\u6b96\u6807\u5fd7\u7269TK1\u662f\u5426\u53ef\u7528\u4e8e\u4e0d\u540c\u539f\u53d1\u80bf\u7624\u4f4d\u7f6eCRC\u7684\u9884\u540e\u8bc4\u4f30\uff0c\u503c\u5f97\u6df1\u5165\u7814\u7a76\u548c\u63a2\u7d22\u3002 […]<\/p>\n","protected":false},"author":3,"featured_media":4745,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[65],"tags":[],"class_list":["post-4731","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-65"],"acf":[],"_links":{"self":[{"href":"http:\/\/www.sstkbiotech.com\/index.php?rest_route=\/wp\/v2\/posts\/4731","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.sstkbiotech.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.sstkbiotech.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.sstkbiotech.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/www.sstkbiotech.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4731"}],"version-history":[{"count":1,"href":"http:\/\/www.sstkbiotech.com\/index.php?rest_route=\/wp\/v2\/posts\/4731\/revisions"}],"predecessor-version":[{"id":4746,"href":"http:\/\/www.sstkbiotech.com\/index.php?rest_route=\/wp\/v2\/posts\/4731\/revisions\/4746"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.sstkbiotech.com\/index.php?rest_route=\/wp\/v2\/media\/4745"}],"wp:attachment":[{"href":"http:\/\/www.sstkbiotech.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4731"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.sstkbiotech.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4731"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.sstkbiotech.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}}}}}}}}}}}}}